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DSIP readily crosses the blood-brain barrier to exert central effects [7] and may enhance inhibitory neuronal activity or modulate sleep-regulating brain regions

In addition, while the homogenous nature of the prescribed dietary intake deficit, physical activity goal and counseling frequency provided consistency, it may not fully reflect the need for approaches tailored to the health profiles of individuals or to different populations in clinical practice

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Rare but serious side effects include pancreatitis (0.3% in trials), gallbladder problems (1.4%), and acute kidney injury (0.7%)